After a recent yum update around early November 2008, my mouse clicking started to have problems. Clicking on icons in the panel would not launch xterm, and clicking on the title bar of windows would maximize them. I also clicked on the Application menu in the panel and they would instantly close.
This was odd mouse behavior.
What I finally discovered is that although I was single clicking, linux was registering them as double clicks.
Changing nautilus or gnome settings didn't affect anything.
After reading this post
they suggested that x was registering clicks on multiple mouse devices. For me it was /dev/input/mice an /dev/input/mouse0. This caused a single mouse click to be repeated.
in my xorg.conf i had the line
Option "Device" "/dev/input/mice"
I changed it to
Option "Device" "/dev/input/mouse0"
and it solved the problem.